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Home > Products >  Tenofovir alafenamide fumarate

Tenofovir alafenamide fumarate CAS NO.379270-37-8

  • Min.Order: 1 Gram
  • Payment Terms: T/T
  • Product Details

Keywords

  • GS-7340
  • Tenofovir alafenamide hemifumarate
  • Tenofovir Alafenamide (GS-7340)

Quick Details

  • ProName: Tenofovir alafenamide fumarate
  • CasNo: 379270-37-8
  • Molecular Formula: C21H29N6O5P
  • Appearance: White to off-white
  • Application: API
  • DeliveryTime: depend on the quantity
  • PackAge: PE bag and AL bag, PE bottle
  • Port: any port
  • ProductionCapacity: 30 Kilogram/Month
  • Purity: 99%+
  • Storage: under 25 degree
  • Transportation: DHL or Fedex
  • LimitNum: 1 Gram

Superiority

Tenofovir alafenamide (INN/USAN, formerly GS-7340) is a nucleotide reverse transcriptase inhibitor and a prodrug oftenofovir. It was developed by Gilead Sciences for use in the treatment of HIV infection and chronic hepatitis B, and is applied in the form of tenofovir alafenamide fumarate (TAF). Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (TDF), TAF has greater antiviral activity and better distribution into lymphoid tissues than that agent.

Gilead announced a phase 3 clinical trial evaluating a single-tablet regimen combining tenofovir alafenamide withcobicistatemtricitabine and elvitegravir and developed a coformulation of the drug with cobicistat, emtricitabine and the protease inhibitor darunavir. In a 48-week study comparing elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil (trade name Stribild) to elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide (trade name Genvoya), the results showed the newer drug to be noninferior to the established agent, but at much lower dosages and with lower incidence of adverse side effects such as impaired kidney function. The FDA approved the TAF-based treatment regimen for treatment of HIV-1 in November 2015. Genvoya is the first TAF-based regimen to receive approval.

Kg grade product, High purity, Low cost and competitive price

Details

ShangHai Hope Chem Co., Ltd is a fine organic chemistry manufacture which located in Zhoupu international medical park. Hope Chem is a high-tech company specializing in customized chemical synthesis and R&D of pharmaceutical intermediates and new drugs. Manufacture of building blocks for life science research Customer chemical synthesis and contract research services to the biotechnology and fine chemical industries.

 Our belief is "Mutual Benefits, High Efficiency". Our company has made great progress these years. We aim at market analysis, technical innovation and constantly get the supports from the universities and scientific research institution. So we can constantly improve the quality and upgrade our products.

 

We insist the principle of "Quality first, customer foremost, best credit and best service, be pioneering and creative", looking forward to establishing good business relationships with customers all over the world. Let's work together for bright future!

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